Effects of concentrated growth factor and collagen fleece on wound healing, palatal tissue thickness, and postoperative comfort at palatal donor site

Objective: The aim of this study was to evaluate the effects of CGF and CF on wound healing, palatal tissue thickness, and postoperative patient comfort at the palatal donor site. Materials and Methods: 38 patients scheduled for autogenous soft tissue graft harvesting were randomly divided into three groups: CGF (n=12), CF (n=13) and control (n=13). Palatal thickness was measured at baseline, 1 and 3 months. Wound healing was assessed on days 7 and 14, and at 1 month using the H₂O₂ test, MMS scale, and LTH index. Pain and comfort were evaluated by analgesic intake, VAS and OHIP-14. Results: Both CGF and CF groups showed significant increases in palatal thickness compared to baseline. At 3 months, the greatest increase was in the CGF group, significantly higher than control (p=0.011). During the first postoperative week, VAS scores were lower in both test groups and analgesic intake decreased in the CGF group between days 4–7 (p<0.05). No significant differences were found in the H₂O₂ test (p>0.05). MMS evaluations revealed earlier color normalization in CGF, while contour normalized faster in both CGF and CF (p<0.05). According to the LTH index, healing began earliest in CGF, with both test groups completing healing earlier than control (p<0.05). OHIP-14 scores improved significantly in all groups by day 14, with functional limitation resolving only in CF (p=0.016). Conclusion: CGF and CF positively influenced the healing process by accelerating wound healing and reducing postoperative morbidity. Keywords: Concentrated Growth Factor, Collagen Fleece, wound healing