Clinical and radiographic evaluation of platelet-rich plasma and bovine derived xenograft combination in the treatment of intrabony periodontal defects

The present study evaluated the clinical and radiographic effectiveness of a regenerative procedure based on combined platelet rich plasma (PRP) and bovine derived xenograft (BDX) application in the treatment of intrabony periodontal defects.Twenty advanced chronic periodontitis patients, aged 37?60 years, were included. A total of 85 intrabony defects with an associated probing depth (PD) of ? 6 and an intrabony component of ? 3 mm were selected. Defects were surgically treated with PRP/BDX. At baseline and 12 months after surgery, the following clinical and radiographic parameters were recorded: plaque and sulcus bleeding indices, PD, marginal soft tissue and relative attachment levels, probing bone and radiographic bone levels.At 12 months postoperatively, clinical and radiographical parameters were improved when compared to baseline (p<0.0001). The mean changes at the deepest sites were: PD reduction of 4.78±1.20 mm, recession of 0.54±0.34 mm, attachment gain of 4.24±1.03 mm, clinical bone gain of 3.75±0.97 mm, and radiographic bone gain of 3.79±1.02 mm.Treatment with a combination of PRP and BDX leads to a significantly favorable clinical and radiographic improvements in intrabony periodontal defects.