Evaluation of the effect of polyvinylpipyridone and sodium hyaluronate gel on palatal wound healing: A randomized controlled clinical trial

The aim of this clinical study was to evaluate the effect of polyvinylpyrrolidone sodium hyaluronate gel on palatal wound healing, pain, and bleeding after free gingival graft surgery. This study included 32 systemically healthy patients who required free gingival graft surgery. After the operation, the test group received polyvinylpyrrolidone sodium hyaluronate gel in addition to chlorhexidine gluconate mouthwash, whereas the control group received only chlorhexidine gluconate mouthwash. VAS scale was used to evaluate palatal pain, burning, and chewing discomfort, WHI was used to evaluate wound healing, and H2O2 foaming test was used to evaluate epithelialization. VAS and bleeding values were recorded on postoperative day 1; VAS, WHI, H2O2, and bleeding values on postoperative days 3, 7, and 14; and WHI, H2O2, and bleeding values on postoperative day 28. When the data obtained from the study were evaluated, statistically significantly lower values were obtained in the test group compared to the control group in the H2O2 foaming test on the 7th, 14th and 28th days (p<0.05). On day 3, no statistically significant difference was observed between the groups in the H2O2 foaming test (p>0.05). On days 3, 7, 14, and 28, WHI values were significantly higher in the test group (p<0.01). On days 1, 3, 7, and 14, VAS pain, chewing, and burning values were significantly lower in the test group than in the control group (p<0.01). On postoperative day 1, 105 times more bleeding was detected in the control group than in the test group (p<0.001). On days 3 and 7, there was no statistically significant difference between the groups in terms of bleeding (p>0.05). The results of this study showed that polyvinylpyrrolidone sodium hyaluronate gel accelerated wound healing and reduced pain and bleeding in the palatal donor area after free gingival graft surgery. KEYWORDS: Bleeding, Free gingival graft, Pain, Polyvinylpyrrolidone sodium hyaluronate, Wound healing