Researching the correlation between surfactant protein-a and surfactant protein-d expression and tumor volume and gleason score in prostatic adenocarcinoma cases

Prostatic adenocarcinoma is the most common cancer in males. After lung cancer, it is the second most common causes of deaths by cancer. Incidence of PCa increases prominently by age. It is an important health care problem especially in countries with long life time. Although advanced therapy and follow-up modalities and long survival rates, there are still many studies on-going about PCa. Surfactant proteins were first determined in lung tissue and thought to be lung-specific for many years. As a result of studies performed up to date, SPs were also shown in joint synovial fluid, gastric and colonic mucosa, periton, pleura, liver, kidney, pancreas, urinary and male-female genital tract. In this study, we searched about SP-A and SP-D expression in prostatic tissue and prostatic cancer tissue and also its correlation with Gleason score and tumor volume. In this study, 35 radical prostatectomy materials were evaluated; tumor volume and Gleason scores were detected and SP-A and SP-D were applied immunohistochemically on tumoral and non-tumoral prostatic tissue. As the results were evaluated; SP-A and SP-D expressions were both seen in tumoral and non-tumoral tissue. In non-tumoral tissue, increased SP-A and SP-D expression was detected in inflammatory regions. This finding supports the relationship between SP-A and SP-D and prostatic immunity. In PCa, increased Gleason score, tumor volume and age correlates with decreased SP-A and SP-D expression. As a result of these findings, reduction in SP-A and SP-D expression can be assessed as a poor prognostic factor.