Evaluation of Claudin-1 and Claudin-4 immunreaktivity at benign, premalign and malign lesions of prostate

Introduction: Prostate carcinoma is the most common cancer of males. It?s second majorcause of male death after lung carcinoma. In this study, prognostic and histological propertiesof prostate carcinoma were investigated by using immunohistochemical markers Claudin-1,Claudin-4.Methods: Our study objects are selected from the archive of Pathology Department ofUnivercity of Düzce from Januvary 2005 to March 2009. We investigated 40 prostatcarcinoma, 37 benign prostate hyperplasia and 37 prostatic intraepithelial neoplasia. Prostatadenocarcinoma cases were classified according to gleason grade, where 1 of them (%2,5)was well differantiated, 12 of them (%30) modorate differantiated and 27 of them were poorlydifferantiated.Results: Age disturubition of groups wasn?t differ from each other. Differantiation ofClaudin-1 expression grade between groups; at PAC group showed generally negative orweak expression. At the PAC group high Claudin-1 expression was proportionally low.Caludin-4 expression density was statistically high at BPH and PIN groups. In BPH group,Claudin-1 and Claudin-4 expressions were possitively correlated. Similarly, in PIN groupClaudin-1 and Claudin-4 found again possitively correlated. But in PCA group, we did notfind any statistical correlation between Claudin-1 and Claudin-4. However, negativecorrelation was found between Claudin-1 and Gleason grade in PCA group. By meaning, highGleason grades assosiated with low Claudin-1 expression. We also found that, Claudin-1expression in benign prostate lesions stronger than prostate adenocarcinoma. So that, Claudin-1 may modulate the histologic features of prostate carcinomas.Conclusion: As a result we conclude that, Claudin-1 and Claudin-4 can be usefull fordiagnosis, which is diffucult to distingush benign-malign lesions of prostate needle biopsies.Key Words: Claudin-1, Claudin-4, Prostate adenocarcinoma, Benign prostate hyperplasia,Prostatic intraepithelial neoplasia