Relationship of serum visfatin level and disease activity in rheumatoid arthritis patients

This study was set to investigate the effect of visfatin serum levels in rheumatoid arthritis patients, and to find correlation of serum Visfatin levels in rheumatoid arthritis patients with disease activity. In the present study that we did on 35 Rheumatoid arthritis patients, the patients study area contain 30 females and 5 males, this indicates that Rheumatoid arthritis disease (RA) Infects the females by a larger percentage than the males, the Visfatin serum levels were much higher with the RA patients compared with the result of control cases. As well, the percentage of visfatin serum increases with the increase of the disease activity where visfatin range was between 7-56 for the severe disease activity and these levels were the highest levels has been recorded it. Visfatin ELISA Kit was used to measure visfatin serum level in both RA patients and controls group. RA patients showed statistically significant higher mean of visfatin serum level than control groups. Also, visfatin serum level showed a statistically significant positive correlation with body mass index. There was a clear relationship between the disease activity and the ESR. Wherever the ESR was high the disease activity was high. Wherever the ESR was high Whenever the patient is in severe inflammation. significant correlation between the visfatin and the ESR. Also, correlation with the rheumatoid factor (RF) and likewise for the ALT test. the correlation continues to include the disease duration too. Disease activity have direct link with ESR, Visfatin and disease duration. Also, the P-value of disease activity score shows it is statistically significant and it have correlation significantly with the age and RF. Keyword: Visfatin, Rheumatoid arthritis, inflammation, Disease Activity, Visfatin Level.