Role of serum resistin hormone level in rheumatoid arthritis its relationship to joint erosion

Study was set to investigate serum levels of resistin in rheumatoid arthritis patients, and compared serum resistin levels between patients and control groups. This study was comprised thirty-five patients with RA disease (30 females and 5 males) and 30 matching age individuals were assigned to be as a control group. Calculation of body mass index (BMI) was carried out for RA patients and controls. Evaluation of disease activity was done using the DAS-28 Erythrocytes Sedimentation Rate scoring system. Resistin ELISA Kit was used to measure serum resistin level in both RA patients and controls group. Statistically, RA patients found to have significant higher mean of serum resistin level than control groups (17.8706 ± 17.9151 versus 10.09728 ± 8.04811 ng/dl respectively (P = 0.467). In addition, serum level of resistin showed a correlation with inflammation biomarker such as C-reactive protein (0.02), erythrites sedimentation rate and disease active score (P = 0.01). No significant correlation was found between serum rersistin level and patients' age, bmi and disease duration.Serum level of resistin was significantly higher in the RA patients than control individuals, no correlation was found between resistin level and Age and BMI. However, the serum resistin level positively correlated with ESR and CRP in the RA patients. Keywords: resistin, rheumatoid arthritis, inflammation, disease activity.