The effect of sodium pyrithione in acute periods on ghrelin and leptin hormone levels in rats

In this thesis study, blood serum ghrelin and leptin hormone levels were investigated in Wistar albino rats after administration of sodium pyrithione (NaPT) and saline in acute periods (24 and 96 hours). As a result of the studies, the comparison of the control groups and dose groups was made. As a result of the comparison, the decrease in ghrelin hormone levels in the acute periods in both dose groups (35 and 70 mg/kg) was found to be significant as a result of statistical analyzes. Again, as a result of the comparison of the dose groups (35 and 70 mg/kg) administered in this study with the control group, the difference in the increase in leptin hormone levels during the acute periods was found to be significant as a result of statistical analysis. The differences in leptin and ghrelin hormone levels between doses at similar time periods were found to be insignificant. The differences between the same doses of NaPT administered over a 24-hour and 96-hour period are insignificant. It is known that NaPT doses administered to rats have cytotoxic effects, resulting in tissue damage and necrosis. As a result of the cachectic effect of these released proinflammatory cytokines, a decrease in ghrelin hormone levels and an increase in leptin hormone levels were detected.