Study of statin effects on plasma lipid profile of patients with dyslipidemia

Dyslipidemia is a major public health problem in developed countries, and it is becoming more common worldwide. Also dyslipidemia is a major risk factor for cardiovascular disease, and it is considered as the first leading cause of death in the world, more people died in Kurdistan region by cardiovascular disease. The aim of this study is to investigate whether anti-cholesterol treatment could effect on plasma lipid profile of patients with dyslipidemia. Twenty-four subjects were taken at Surgical Specialty Hospital Cardiac Center in Erbil city and diagnosed by dyslipidemia. Blood sample collections started in 20,02,2016 and finished in 20,04,2016. The present study included 12 patients (6 males and 6 females) who had dyslipidemia as patient group and 12 individuals (4 males and 8 females) who had no dyslipidemia as healthy group, patient and healthy groups aged >30 years old. The results of this study showed that the concentration of total cholesterol (TCH) and triglyceride (TG) were significantly higher about 66,7% or in 1,67 times and 69,5% or in 1,69 times in patient group before treatment with atorvastatin than that of control group, while they were decreased after treatment with atorvastatin. The concentration of low density lipoprotein (LDL) was significantly higher about 42,8% or in 1,42 times in patient group before treatment with atorvastatin than that of control group, it is decreased after treatment but not significantly. Meanwhile, the concentration of high density lipoprotein (HDL) was significantly lower about 23,5% or in 1,3 times in patient group before treatment with atorvastatin than that of control group, it is increased after treatment with atorvastatin. The concentration of CHOL/HDL was not significantly higher in patient group before treatment with atorvastatin as it compares with control group, it is decreased non-significantly after treatment with atorvastatin. On the other hand, the concentration of creatinine was not significantly higher in patient group before treatment with atorvastatin than that of control group, it is decreased after treatment but not significantly. The concentration of urea was significantly higher in patient group before treatment with atorvastatin than that of control group, it is decreased after treatment but not significantly. The concentration of glucose was significantly higher in patient group before and after treatment with atorvastatin than that of control group, it is decreased about 34,8% or in 1,34 times after treatment but not significantly. The mean value of erythrocyte sedimentation rate (E.S.R) was significantly higher in patient group before treatment with atorvastatin than that of control group, it is decreased after treatment with atorvastatin but not significantly, but there is significant difference in mean levels of (E.S.R) in patients before and after treatment with atorvastatin. Observed results show multifactorial effect of atorvastatin on lipid metabolism and main clinical indices, as urea and creatinine. Taking together, obtained data evidence soft positive effect of statin for symptom data of patients with dyslipidemia