Investigation of factors affecting hpv persistence in patients with total hysterectomy

Cervical cancer is one of the most common types of cancer among women, representing a significant public health concern due to its high mortality and morbidity rates. High-risk human papillomavirus (hrHPV) infections are recognized as the primary cause of cervical cancer development. Understanding the persistence of HPV infections in women who have undergone total hysterectomy is critical for clarifying the underlying mechanisms of premalignant and malignant processes. This retrospective study examines the medical records of women diagnosed with HPV persistence after hysterectomy. The study evaluates variables such as age, parity, educational level, smoking habits, HPV type and subtyping, surgical indications, immune status, and sexual history. These factors were analyzed to identify potential risk factors influencing the persistence of HPV infections and to understand the mechanisms underlying the infection's progression. Existing literature highlights that HPV persistence is associated with factors such as smoking, age, immune system status, and sexual behavior. However, studies specifically investigating HPV persistence after hysterectomy remain limited. This research is significant in identifying individual and environmental factors contributing to the continuation of HPV infections and their clinical implications. Preventing HPV persistence is essential to mitigating malignant transformation and highlights the importance of developing effective follow-up programs. The findings of this study are expected to contribute to public health initiatives aimed at preventing HPV-related diseases and improving overall community health. In this study, HPV persistence and the associated risk factors for VaIN development after hysterectomy were evaluated. The findings showed that age is a significant risk factor for HPV persistence, with the risk increasing as age progresses. Additionally, smoking was found to be significantly associated with HPV persistence. HPV 16 was identified as the most influential HPV type in the development of persistence and VaIN, highlighting that patients with this type are at higher risk. Furthermore, the detection of VaIN in all patients with a history of high-grade lesions (HSIL) emphasizes the need for closer postoperative follow-up in this patient group. These results contribute to a better understanding of the factors associated with HPV persistence and VaIN development and aid in identifying high-risk groups.