Effects of platelet rich plasma on fast and slow investigation of tissue expansion

Tissue expansion , tissue defects that can not be closed primarily , with the help of neighbors Tap the balloon expanded in terms of color and texture match with tissue repair is a technique that is similar . Tissue expansion of the major advantages of the method of reconstruction next step requires a long time for treatment , frequent doctor's supervision in order to secure inflated to disrupt the patient's comfort and is preparing the ground to complications such as infection . Time to be made to reduce the loss as a result of rapid tissue expansion procedures may deteriorate if the circulation is increasing the frequency of occurrence of necrosis . In both fast and slow tissue expansion procedures for the reduction of complications is trying to develop new methods . Platelet- rich plasma content because of the numerous growth factors , as in every field of medicine in plastic surgery has been used with increasing frequency . The aim of this study PRP positive effects on angiogenesis and tissue remodeling advantage of fast and slow tissue expansion process is to observe the effects on them . For this purpose, 42 g of 350-450 . Weight in the female rats were randomly divided into 6 groups . 7 selected as a donor for the preparation of PRP from another rat blood was taken with the entire body . Preferably blood is centrifuged prepared with PRP , tissue expansion scheduled region , according to groups at different times was injected and the expanders fast and slow inflated methods raw they ( Group 1 : Fast tissue expansion treated control group, Group 1B: Slow tissue expansion treated control group Group 2A: PRP 1 week after rapid tissue expansion done , Group 2B: PRP 1 week after slow tissue expansion the group , and Group 3 : PRP application on the same day rapid tissue expansion done , Group 3B: PRP application with the same days with slow tissue expansion group ) . Evaluation with the aim of expanding the action bits 7 days after taking samples from the peak of tissue expansion , Histology and Embryology laboratory for histological evaluation , ELISA was delivered to the laboratory for evaluation of Medical Pharmacology . In 3 subjects in Group 1A , Group 1B in the second subject , Group 2A and Group 2B of the first expansion action in the subject application region formed at the peak was observed that more than 50% necrotic areas . PRP was a reduction in the invasion of neutrophils in the group . PRP was given 1 week before a tissue expander action groups in the number of newly formed vessels , rapid tissue expansion is applied , and in all the groups given PRP expressed significant increase in bFGF and VEGF were detected . Also given PRP slow tissue expansion process and rapid tissue expansion process in the groups treated with the same day capsule in the PRP group given that a significant reduction in thickness was observed. PRP obtained easily , with low side effect profile product is autologous . Which include the effect of growth factors and pro-active cells shows through . In our study, the expansion of this product during the process of tissue necrosis, which reduces one of the major complications that can occur , that enables the expansion will result in the achievement of action increases the formation of new blood vessels and showed that it reduces the thickness of the capsule . Easy to obtain further research to be done with these two autologous tissue expansion process of the product can be safely used in the more we think.