Synthesis , characterization of novel non-steroidal anti-inflammatory drugs and evaluation of their anti-cancer potentials in human glioblastoma cell line

Glioblastoma Multiforme (GBM) is one of the most malignant brain tumors classified as grade IV by WHO (World Health Organization) accounts for one in four of all primary brain tumors. The treatment options of GBM is so limited and the median survival is still short. Thus, new treatment approaches are necessary to prolong this limited life time. In this study we aimed to synthesize new NSAID prodrugs (Ibuprofen, Naproxen ve Flurbiprofen) and investigate in vitro cytotoxic effects of these NSAID prodrugs on U-87 MG human GBM cell line. U-87 MG GBM cell cultures were treated with 9 different NSAIDs (3,125; 6,25; 12,5; 25; 50 ve 100 g/ml) for 48 hours, Cell viability was investigated with MTT assay. Then, membran integrity was determined with LDH assay. According to the our results NSAID prodrugs exhibited dose dependent cytotoxic effects on U-87 MG GBM cell line when compared with the control group. The cytotoxic and anti-cancer effects of novel NSAID prodrugs on U-87 MG human GBM cell line were investigated for the first time.