The synthesis of proton transfer salts between 2 amino-3-methylpyridine and sulfamoylbenzoic acid derivatives and their metal complexes, and studies on their biological applications

In this study, two novel proton transfer salts (psba2a3mp and 2MeO5sba2a3mp) have been prepared between 4-sulfamoilbenzoic acid (Hpsba) and 2-methoxy-5-sulfamoilbenzoic acid (H2MeO5sba) and 2-amino-3-methylpyridine (2a3mp), acid derivatives and their Cu(II) complexes have also been synthesized. The structures of amorphous proton transfer salts have been characterized by elemental analysis, 1H-NMR, FT-IR and UV-Vis methods while the structures of amorphous metal complexes have been proposed by elemental analysis, ICP-OES techniques, FT-IR, UV-Vis, magnetic susceptibility and molar conductivity methods. Besides, the antibacterial and antifungal activities of the starting materials, salts and their complexes were investigated in vitro against to Escherichia coli (ATCC 25922), Staphylococcus aureus (ATCC 29213) (Gram positive), Enterococcus faecalis (ATCC 29212) (Gram negative), Candida krusei (ATCC 6258) (yeast) and Candida parapisilozis (ATCC 22019) (yeast). The results have been compared with Levofloxacin, Cefepim, Vancomycin and antifungal compound Flucanozole antibacterial control compounds minimum inhibitory consantration (MIC) values of the investigated compounds were found in the range of 31,25-125 µg/mL, 31,25-250 µg/mL, 31,25-250 µg/mL, 62,50-500 µg/mL and 31,25-125 µg/mL, respectively.