N-heterocycic carbene precursors and complexes with 4-florobenzyl group

N-heterocyclic carbene (NHC) ligands have unique properties such as strong σ-donor and weak π-acceptor properties, tunability of steric and electronic properties of substituents on the nitrogen atom, and the ability to form stable bonds with metals. As an important class of organic and organometallic chemistry, NHCs and their metal complexes are widely used in medicinal chemistry, materials chemistry, and chemical catalysis. The judicious incorporation of fluorine into a molecule can efficiently influence its conformation, pKa, intrinsic potential, membrane permeability, metabolic pathways, and pharmacokinetic properties. Consequently, the development of efficient methods for the insertion of fluorine groups into target molecules has become an important area of research. The main purpose of this thesis study is that the inclusion of the fluorine atom with the highest electronegativity in the carbene precursor and their complexes will affect the lipophilic properties of the drug precursors to be synthesized, which will affect both the intracellular permeability and biological activity in the body and contribute to the synthesis of new generation drugs. Within the scope of this thesis; 1) Fluorinated benzimidazolium salts (2a-h), NHC-Ag(I) (3a-g), NHC-Pd(II)-pyridine (4a-g), NHC-Pd(II)-(2-aminopyridine) (5a-d) complexes were synthesized and their structures were elucidated by appropriate spectroscopic methods. 2) The inhibition activities of the enzyme of fluorinated benzimidazolium salts (2a-h) were investigated. 3) Molecular docking study has been done. 4) In silico ADMET study was performed. Keywords: N-heterocyclic carbene precursors; Benzimidazole; NHC-Pd(II)-pyridine complexes; NHC-Pd(II)-(2-aminopyridine) complexes; NHC-Ag(I) complexes; Enzyme inhibition