The effect of hysteroscopic treatment on in-vitro fertilization treatment outcomes in patients with unexplained infertility having endometrial polyps or uterine septum

Balkış, Ç. The effect of hysteroscopic treatment on in-vitro fertilization treatment outcomes in patients with unexplained infertility having endometrial polyps or uterine septum. Eskisehir Osmangazi University Medical school, Department of Obstetrics and Gynecology Medical Specialty Thesis, Eskisehir, 2024. In this study, we aimed to investigate the effect of hysteroscopic treatment on in-vitro fertilization treatment outcomes among patients with unexplained infertility who had endometrial polyps or uterine septum. This retrospective study was conducted on a total of 436 patients who underwent IVF (in-vitro fertilization) due to unexplained infertility at the Reproductive Health Center of the Department of Obstetrics and Gynecology of our hospital between January 2020 and 2023. Patients were divided into three groups as; women who underwent hysteroscopic polypectomy, uterine septum incision and no operative hysteroscopic treatment before assisted reproductive treatments. The study examined parameters including biochemical pregnancy rate, clinical pregnancy rate and live birth rate . In control group, the biochemical pregnancy, clinical pregnancy and live birth rates were 8.4%, 41.7% and 31.5%, respectively. In polypectomy group these rates were %6.8, %20.6 and 13.7% for the same parameters, while in septum incision group these rates were 17.6%, 29.4% ve 23.5%, respectively. Statistical analysis revealed no significant differences between the groups in terms of biochemical pregnancy, clinical pregnancy and live birth rates (p:0,395, p:0,50, p:0,111). This study showed that both hysteroscopic metroplasty and polypectomy did not have a significant positive impact on the reproductive outcomes in cases whose IVF treatment was planned due to unexplained infertility. In addition, although IVF and pregnancy result were shown to be statistically similar in both groups to those with normal uterin cavity, slightly lower pregnancy result were obtained in patients operated for uterine septum and endometrial polyp. Key Words: Unexplained infertility, IVF, septal uterus, polypectomy