Evaluation of serum uric acid and aterogenic index parameters in hemodialysis patients with and target parathormone value in Adiyaman province

Aim: Cardiovascular disease (CVD) is the main cause of morbidity and mortality in patients with end-stage renal failure (ESRD). In dialysis patients; vascular damage is more common than the general population due to uric acid (ÜA), hypoalbuminia, dyslipidemia, inflammation, oxidative stress and vascular calcification. In this study, we examined the relationship between atherogenic index and uric acid levels and parathormone (PTH), noninvasive laboratory methods for cardiovascular risk in dialysis patients. Material and Method: Our study, which has a retrospective design, included 91 dialysis patients, 18 years of age and over, who were followed by nephrology outpatient clinic. Patients according to parathormone (PTH) levels; low PTH levels (PTH <136) were categorized as Group-1, target range PTH levels (136≤ PTH <612) as Group-2, and high PTH levels (PTH≥ 612) as Group-3. All comparisons have been conducted through these three groups. The collected data were analyzed by SPSS22.0 and the statistical significance level was considered as p<0.05. Results:The mean age of the patients was 53.48 ± 18.41 and 49.5% (n=45) were female patients. In comparison, the groups differed in terms of ÜA levels (p<0.05). Group-1 uric acid level was lower than Group-2 (p<0.05) and Group-3 ÜA level was lower than Group-1 (p<0.05). Group-2 and 3 had similar ÜA levels (p > 0.05). Compared with plasma atherogenic index (PAI) levels, there was no significant difference between groups (p>0.05). Conclusion: In our study, it had the lowest UA levels in the target PTH Group compared to other groups, PTH and UA levels were correlated. There was no correlation between PTH and PAI, PTH groups had similar PAI levels, but although not significant, PAI levels were increasing from Group-1 to Group-3. KeyWords:Uric acid, plasma atherogenic index, parathormone