Alerjik rinit, ovalbumin, melatonin, sıçan, Ovalbumin-spesifik IgE

Objective: To investigate the therapeutic effects of melatonin in the ovalbumin-induced rat allergic rhinitis (AR) model. Method: Wistar rats were divided randomly into control, ethanol, saline (SF) and melatonin groups. The experimental AR model was established with ovalbumin in melatonin, ethanol and SF groups; 10 mg/kg melatonin, ethanol, and saline were administered, respectively. Total nasal symptom scores were recorded on days 1,15, 20, 25 and 30; serum Ovalbumin-specific IgE, IL-13, and melatonin were measured on days 1, 15 and 30. Nasal mucosa of rats was scored histopathologically. Results: All baseline measurements of the groups were similar (p>0.05). The nasal symptom scores were higher in SF, ethanol and melatonin groups on day 15 compared to the control group (p<0.05). On day 30, the scores of SF and ethanol groups were higher than control (p<0.05), while the melatonin group was similar to the control (p>0.05). On day 15 and 30, Ovalbumin-specific IgE values of SF and ethanol groups were higher than control (p>0.05). On day 30, the results of the melatonin group were similar to the control (p> 0.05), while those of the SF and ethanol groups were higher than control (p<0.05). There was no difference between serum IL-13 and melatonin values between groups(p>0.05). Histological scores of ethanol and SF groups were higher than the control and melatonin groups (p<0.05), while control and melatonin groups were similar(p> 0.05). Conclusion: Melatonin improved nasal symptom scores, serum ovalbumin specific IgE, and histological inflammation parameters in ovalbumin-induced rat allergic rhinitis model.