Investigation of the effects of concentrated growth factor and platelet-rich fibrin on postoperative pain, edema and recovery in extractions of sub-embedded wisdom teeth

Extraction of impacted lower wisdom teeth is one of the most common surgical procedures in oral, dental and maxillofacial surgery. This surgical procedure usually involves trauma that stimulates a series of physiologic, cellular responses. This leads to postoperative symptoms such as trismus, edema and pain. Various methods have been applied to reduce these complications. One of the methods used to reduce these effects is autologous blood products such as PRF-CGF. In our study, we aimed to investigate the effects of CGF, which contains richer growth factors and has a denser fibrin structure compared to PRF, on postoperative pain, edema and wound healing compared to PRF. In our study, the information, forms and X-rays of 30 patients over the age of 18 who underwent bilateral impacted lower wisdom tooth surgery between December 2021 and December 2022 at Süleyman Demirel University Faculty of Dentistry, Department of Oral, Dental and Maxillofacial Surgery were used. In our study, pain was evaluated by VAS on postoperative days 2 and 7, edema was evaluated by measuring the distances between the tragus and the corner of the mouth, tragus and pogonion, and lateral eye corner and angulus, and wound healing was evaluated by LTH wound healing index on postoperative day 7. The results were evaluated statistically. In our study, when the effects of CGF and PRF application on wound healing, postoperative edema and postoperative pain were examined; it was found that CGF gave better results in wound healing and reduced pain more than PRF. It was found that CGF was not statistically different from PRF on postoperative edema. Keywords: Impacted lower wisdom tooth, Platelet Rich Fibrin (PRF), Concentrated Growth Factor (CGF), Postoperative Edema, Postoperative Pain, Wound Healing