Serum lipid, apoprotein, lipoprotein and HDL subfraction analysis in patients with coronary artery diseases diagnosed angiographically

SUMMARY SERUM LIPID,APOPROTElN, LIPOPROTEIN AND HDL SUBFRACTION ANALYSIS IN PATIENTS WITH CORONARY ARTERY DISEASES DIAGNOSED ANGIOGRAPHICALLY SERVET (İNAN) KIZILDA? Atherosclerosis, which causes coronary artery disease, and its complications are the leading cause of the death throughout the world. High trigliyceride and total cholesterol levels are the main risk factors in the development of the disease. High serum LDL and low HDL levels are also important risk factors in the development of atherosclerosis. Many authors claim that low HDL levels is due to decreased HDL2 fraction. Apoproteins, which are protein components of lipoproteins, are responsible for binding of lipoproteins to their specific receptors and they have a vital role in lipoprotein metabolism. In this study, we have proposed to study the role of serum lipid, lipoprotein, apoproteins and HDL subtractions in the development of coronary artery disease and atherosclerosis and we have compared the results of the patient group with those of the control group. 43 male (age 59.9±10.3) and 10 female (age 60±8.4) in patient group and 9 healthy male (age 57.5±12.8) and 1 1 healthy female (age 56.5+1 1.5) in control group were included in the study. Fasting serum triglyceride, total cholesterol, HDL cholesterol, HDL2 cholesterol, HDL3 cholesterol, LDL cholesterol, apo AI, apo B levels and total cholesterol/HDL, HDL2/HDL3, apo AI/apo B, apo B/apo AI ratios were studied in patient and control groups. These results were as follows in males with coronary artery disease; 168.9±78.6*, 237.6*72.6*, 34.2±8.3*, 12.6±6.0*, 21.6±6.3*, 171.1±67.8*, 104.3±16.3*, 120.4±29.3*, 7.3±2.6, 0.6±0.4, 0.8±0.1, 1.2±0.2, These results were as follows in females with coronary artery disease; 149.1±36.2*, 260.6±28.4*, 31.0±6.5*, 11.3±4.0*, 19.7±5.6*, 199.8±27.0*, 106.7±17.6*, 129.Ü29.1*, 8.2±2.1, 0.6±0.3, 0.8±0.2, 1.2±0.3, These results were as follows in males control group; 124.3±71.0*, 196.7±30.2*, 46.5±16.6*, 21.7±11.7*, 24.7Ü0.5*, 125.3±32.4*, 113.6±24.5*, 99.1±32.9*, 4.7±1.8, 1.0±0.6, 1.3±1.0, 0.9±0.3, These results were as follows in female control group; 151.4±35.1*, 219.1±44.5*, 37.0±9.1*, 16.0±9.6*, 21.0±6.9*, 151.8±40.7*, 110.9±22.2*, 119.Ü31.9*, 6.0±1.4, 0.8±0.7, 0.9±0.3, 1.1±0.3. In males with coronary artery disease triglycerid (p=0.0277), total cholesterol (p=0.0418), LDL cholesterol (p=0.0226), apo B(p=0.0Q44) levels and total cholesterol/HDL (p?=0.0021), apo B/apo AI (p=0.0118) ratios were increased whereas HDL cholesterol (p=0.0277), HDLa cholesterol (p=0.0226), HDL3 cholesterol (p=0.0431), apo AI (p=O.0339) levels and HDL2/HDL3 (p=Q.Q421), apo AI/apo B (pK).0171) ratios were decreased when compared with that of control groups. In females with coranary artery disease total cholesterol (p=0.0357), LDL cholesterol (p=0.0101), apo B (p=0.0467) levels and total cholesterol/HDL (p=0.0295), apo B/apo AI (p=0.0387) ratios were increased and HDL cholesterol (p=0.0410), HDL2 cholesterol (p=0.0340), apo AI (p=0.0349) levels and apo AI/apo B (p=0.0386) ratios were decreased when compared with that of control groups. We could not obtain statistically significant difference when we compared in females triglyceride (p=0.7045), HDL3 cholesterol (p=1.000) level and HDL2/HDL3 (p=0.9725) ratio with that of control group. All data shows that HDL2 and HDL3 cholesterol levels have an important role in the development of atherosclerosis and determination of HDL2, HDL3 levels and HDL2/HDL3 ratio is a invalid tool to identify atherosclerosis risk profile. It also shows that total cholesterol/HDL, apo AI/apo B, apo B/apo AI are more valuable than sole lipoprotein levels. (*) : mg/dl Key words: Atherosclerosis, CAD, HDL subfractions, Lipoproteins, Apoproteins