Electrochemical analysis of antiinflammatory dDUG nimesulide using multiwall carbon nanotubes modified carbon paste electrode

Electrochemical properties of nimesulide which is antiinflammatory drug were investigated in the direction of oxidation with carbon paste electrode modified with multiwalled carbon nanotubes obtained with dropping method by cyclic voltammetry, differential pulse voltammetry, and square wave voltammetry. Determination studies of optimum buffer solution were done for electrochemical analysis of antiinflammatory drug nimesulide. For this purpose, pH scanning was carried out at different pH buffer. The analysis of nimesulide solution in different buffer solutions were found to be irreversible redox reaction. The oxidation of nimesulide showed diffusion controlled behaviour with scan rate study. The linearity range was determined as 6×10-8-1×10-5 M (correlation coefficient 0.992), the limit of detection 1.07×10-9 M and limit of quantification 3.24×10-9 M in the calibration work of nimesulide with DPV. The results of calibration graph obtained with DPV were compared with the results in the literature. Analysis of pharmaceutical dosage form of nimesulide in the final step of the study was carried out without any separation and filtration processes. As a result of the studies, anti-inflammatory drug nimesulide gave a good degree of precision, high accuracy, and sensitivity using DPV method with carbon paste electrode modified by dropping method of multi-walled carbon nanotubes.