Design, syenthesis of new thiadiazole derivatives with anticancer effect and research of their biological activities

Cancer continues to be a highly prevalent and high mortality disease. It is very important to develop compounds with less toxicity and higher therapeutic efficacy for antitumour compounds.In this master thesis, new compounds containing 1,3,4-thiadiazole structure were synthesized based on 3,4-dimethoxyphenylisothiocyanate compound. These compound structures were elucidated by 1H-NMR, 13C-NMR and HRMS spectroscopic methods.The activities of obtained compounds on the aromatase enzyme have been studied. As a result of biological activity tests, the interaction of compound 3c with the aromatase enzyme and its biological activities were investigated using molecular docking methods.