The possible protective effects of some Hypericum species against cyclophosphamide based on cell toxicity

Although it is one of the most common drugs using in cancer treatment, cyclophosphamide (CP*) is known with its harmfull effects on bone marrow (KI), leukocyte (WBC), erythrocyte (RBC) and thrombocyte (PLT). Recenty, it has been used many plant extracts so that it can be eliminated the damages caused by CP* with the help of this information, It is thought that some Hypericum L. (Hyp) species may also be effective against CP* induced cell damage. In this study; ın rats KI and blood, 50 mg / kg given intraperitoneally (ip) as a single dose of CP* against 3 different Hyp species with known antioxidant properties (H. perforatum L. (HP), H. origanifolium Willd. (HO) and H. montbretii Spach. (HM)) doses of 50 mg / kg of leaf metanol extracts (HPE, HOE and HME, respectively) were given orally once a day in 5 days. As a conclusion; leaf metanol extracts belong to Hyp species (especially HOE, HME and HPE, respectively) were found to have crucial effects against the supresion of KI (Myelosuppression) and decrease in the number of leukocytes (Leucopenia) in the blood caused by the induced-CP*. Key Words: Cyclophosphamide, Hypericum, Bone Marrow, Blood Cells