Studies on synthesis biological activity and molecular modeling of some thiazolylaminoacetylthioimidazole derivative compounds

Different structural variations of the central ring in tricyclic structures have been a popular area of research for selective COX-2 inhibition. It is also known that thiazole derivatives have different pharmacological activities. In this study, 1,5-disubstitued phenyl-imidazole-2-thiol and N-thiazole acetamide structures were introduced into the reaction to give 9 new 2-[(1,5-diphenyl-1H-imidazol-2-yl)thio]-N-(thiazol-2- yl)acetamide derivative (Compound 1-9). The COX-1 and COX-2 inhibitory activities of these synthesized compounds were tested by enzyme experiments. Interactions between the active compound and the active site have been elucidated by molecular modeling studies. Keywords: 1,5-Diarylimidazoles, COX-1/2, Molecular modeling