Synthesis and structural identification of some new benzothiadiazine-related derivatives

The aim of this work is to synthesize some new 4H-1,2,4-benzothiadiazine 1,1-dioxide derivatives with a new aproach and identify their structures by means of spectral and physical data. This research work has been constructed primarily based on the synthesis of some 3-aryl-4H-1,2,4-benzothiadiazine-1,1-dioxide derivatives and then determina-tion of their structures. Novelty of the chemistry can be described as follows; ben-zothiadiazine 1,1-dioxide derivatives exhibit various important biological activities and some of them are currently being used as medicines containing benzothiadiazi-ne 1,1-dioxide skeleton. For this reason, major purpose is to obtain these compo-unds by incorporating chloromethyl oxadiazoles by means of microwave irradiation or otherwise classical methods. The new compounds to be obtained will be elucida-ted by means of spectroscopic and physical methods. In summary, within this work, despite the difficulties encountered during the experiments, we succesfully synthesized 8 new benzothiadiazine-1,1-dioxide deri-vatives carrying 1,2,4-oxadiazolylmethyl group at 4-position of the benzothiadiazine ring. Synthesis of amidoximes and chloromethyl oxadiazoles as starting materials were carried out and their nucleophilic substitution reaction with benzothiazines dioxides were performed leading to target N-substituted products. All of these compounds are new and original and they are considered to make a remarkable contribution to the literature of synthetic organic chemistry. It is strongly possible that the compounds are potentially bioactive due to having the main skeleton and substituents. But, unfortunately, at the moment, we were not able to conduct a bioactivity screening of the compounds due to the low amounts of them and, in addition, regarding unrecoverable from DMSO-d6 NMR solutions.