The synthesis and characterization of benzothiazole substituted pyrazole-4-carbaldehyde and different acridine derivatives

Acridine is a heterocyclic organic compound. Acridines have important roles in drug chemistry and organic chemistry. This first use of acridine and derivatives was realised as drug and antibacterial material. Recently, so many acridine derivatization and synthesis methods were developed with the aim useing in chemotherapic drugs as especialy anti-tumor agents. Pyrazoles is a compound class of having different pharmacological properties such as anti-inflamatuary, anti-viral, antimicrobial and anticancer activities. In our study, the synthesis of new pyrazole-acridine derivatives containing substituted bioactive groups such as pyrazole, benzothiazole and sulfonamides. The affects of these bioactive groups are knwon in drug production and biological fields. In this study, 1-(benzo[d]thiazole-2-yl)-3-(4-bromophenyl)-1H-pyrazole-4-carbaldehyde compound as our starter and cyclohexane-1,3-dione compounds were refluxed in dichloromethane with the catalysis of p-TSA. After a while, different amine derivatives were added to reaction mixture. As a result acridine derived compounds such as (SA-1), (SA-2), (SA-3), (SA-4), (SA-5), (SA-6), (SA-7) were obtained. The structures of already obtained compounds emerged with the help of IR, 1H-NMR, 13C-NMR and MASS spectral data.