Some applications of benzotriazole compounds in synthetic chemistry

Nowadays, therapeutic applications of peptides and small peptide-like chains (peptidomimetics) have gained much attention in pharmacological sciences.In the present study, peptidomimetic compounds including ?-aminoxy peptides, depsipeptides and their hybrid analogs were prepared by using novel synthetic methodologies. Many new synthetically useful intermediates including N-(PG-aminoacyl)benzotriazoles, N-(PG-?-aminoxyacyl)benzotriazoles, O-PG(?-hydroxyacyl)benzotriazoles were prepared from their carboxylic acid analogs and their synthetic utilities were demonstrated by the preparation of some novel biologically active compounds depsipeptides, depsides, chiral oligoesters, ?-aminoxy peptides and ? -aminoxy hybrid peptides in high yield without causing racemization.