Clinical importance of the first trimester uterine artery doppler measurements in patients wi̇th hyperemesis gravidarum

Aim: To compare the first trimester uterine artery doppler measurements, biochemical markers of the first trimester antenatal screening test and severity of hyperemesis gravidarum according to PUQE score. . Material and methods: A prospective study was carried out in Bezmialem Vakif University Hospital, between 17 December 2016 and 17 March 2017, after ethics committee approval. A total of 207 consecutive patients were evaluated, all singular pregnancy with positive fetal heart rate, at 11th to 14th week of gestations. The demographic data of the patients such as age, gravida, parity and body analyses such as body mass index (BMI), height, weight were recorded. Ketonuria and urine analyses results were recorded as laboratory parameters. The diagnosis of hyperemesis gravidarum was based on the score of PUQE test. According to PUQE test score, the patients divided into two groups. The control group (Group I) included those with PUQE score < 6 and the study group (Group II) included those PUQE score ≥7. First trimester antenatal screening test and uterine artery doppler measurements were performed for the all patients. A total of 207 cases consisting of 131 Group I cases and 76 Group II cases were evaluated. We compared the first trimester uterine artery doppler measurements and biochemical markers of the first trimester antenatal screening tests between two groups. Statistical analysis were performed using SPSS v21 (Statistical Package for Social Sciences Chicago, USA); student-t, Anova, Mann-Whitney U and chi-square tests were used. And the level of significance was set at p<0,05. Results: A total of 207 cases consisting of 131 Group I cases and 76 Group II cases were evaluated. Right and left uterine artery PI, RI, mean PI, mean RI, presence of bilateral notch were found similar between two groups (p>0.05). No significant relationship was found between PAPP-A (p=0,9), B-HCG (p=0,5), NT mom (p=0,9) and PUQE scores of the patients in two groups. There was no significant difference between the groups in terms of age, gravida, parity, BMI, (P>0.05). There was also no significant differnce in terms of presence of leucocytes in urine analysis (p>0,4). But, there was a significant difference between the groups in terms of ketonüria (p=0,01). We see ketonüria more frequently in Group II (17,2 % vs 2,4% respectively). Conclusions: We didn't found any correlation between the first trimester uterine artery doppler parameters, biochemical markers of the first trimester antenatal screening test and severity of hyperemesis gravidarum according to PUQE score, in our study.