Biyobozunur substrat modellenmesi için mikrofabrikasyon stratejileri

Replacing the non-degradable materials with the biodegradable ones is a crucial strategy for removing environmental waste and boosting eco-friendly practices. In this sense, in the recent years, both in the medicine and industry, non-degradable materials are being replaced with their degradable alternatives. Cell culturing applications, drug delivery applications, and fabrication of other implantable medical devices are some examples where the biodegradable alternative materials are highly desired. The processability of the biodegradable substrates significantly depend on the microfabrication method that is chosen to process it. For this reason, in order to make use of the biodegradable materials, providing a detailed examination of the microfabrication strategies for the patterning of biodegradable substrates is very critical. This thesis investigates the conventional and unconventional fabrication methods to craft microstructures on biodegradable PLA substrate. As the PLA is a very sensitive biodegradable material, the use of conventional microfabrication methods such as photolithography, microstamping, and laser ablation is very limited in the laboratory as well as in the industry. In this work, stencil lithography using DRIE-based Si-stencils for both PLA etching and material deposition simultaneously are utilized. In addition to separately etching and depositing metals on substrates, a molybdenum electrode embedded inside PLA substrate is demonstrated. While the average resistance is measured as 796.45 Ω when the electrodes are on top of PLA substrate, the average resistance is measured as 2.0297 kΩ when the electrodes are embedded inside the PLA substrate due to the roughness caused by etching. Overall, we provide a handbook to wisely select a protocol for large area and high throughput fabrication of any microstructure on PLA biodegradable substrate, which can be extended to a variety of other sensitive biodegradable materials.