Synthesis and properties of a NIR imaging agent that contains boron

Cancer is the uncontrolled or abnormal division and proliferation of cells with the accumulation of mutations in the DNA molecule. Many methods are used to treat it, one of which is surgical removal of the tumor. It is very important to remove as much tumor as possible and simultaneously to avoid unnecessary damage to healthy tissues. However, the success of the operation may largely depend on the experience and skills of the surgeons performing the operation. In order to increase the success level of the operation, fluorescence guided surgery has been suggested recently. In this thesis it was aimed that synthesized and characterized of a NIR dye that fluorescent in near infrared region. This dye that designed internalized easily with cancer cells. In further studies, tumor cells have been imaged and thought that it can be used in fluorescence guided surgery. At the same time, successful results were seen in in vitro studies with the developed dye photosensitizer feature. Also this dye contains highly amount of boron for potential boron neutron capture therapy (BNCT).