The effect of triamsinolone asetonid and clioquinol to prevent epidural fibrosis on the after experimental laminectomi

Lumbar pain is one of the most frequently seen health problems. Lumbar disc hernia is the most common cause of lumbar pain. In lumbar pain disease, ?Unsuccesfull Lumbar Surgery Syndrome? (ULSS) is seen on about 15% of patients (13, 14). One of the most important factor causing failure of Lumbar disc hernia surgery is epidural fibrosis.In our study, investigated the effects of Triamcinolone Acetonid and Clioquinol for prevention of seen epidural fibrosis after experimental laminectomy on rats.Total 46 winstar race male rats in 7 groups were used in the study. L3 and L4 total laminectomy were appiled to rats under anesthesy of ketamine and xylazin. Any surgical procedure or medical treatment was not given to the rats in Sham group. In the control group, normal saline was applied to the area. Intra operative epidural triamcinolone acetonid 10 mg/kg was applied to third group. Intra operative epidural Clioquinol 20 mg/kg was applied to fourth group. Intra operative epidural triamcinolone acetonid 10 mg/kg and Clioquinol 10 mg/kg were applied to fifth group. Intra operative epidural triamcinolone acetonid 10 mg/kg and Clioquinol 20 mg/kg were applied to sixth group. Finally, Intra operative epidural triamcinolone acetonid 10 mg/kg and Clioquinol 40 mg/kg were applied to seventh group. Subjects sacrified using sodium pentotal at lethal dose at the end of the sixth week.Pathology samples prepared from sacrified subjects were painted with hemotoxilen eozine and Mason tricrome. Samples were evaulted for foreign substance reaction, inflamatory cell density, fibroblast cell density and scar forming under light microscope, and scored by using semicantitative scale. According to result, Triamsinolon asetonid (10mg/kg) coluld not prevent epidural fibrosis after experimental laminectomy. On the other hand, Clioquinol 20 mg/kg significantly decreased epidural fibrosis after experimental laminectomy. We think that Clioquinol maybe used to prevent of epidural fibrosis occurred after laminectomy.