The diagnostic value of pentraxin-3 in deep vein thrombosis

Objectives: We investigated the diagnostic value of Pentraxin 3 (PTX-3), a marker that increases in vascular and inflammatory pathologies, in patients admitted to hospital with deep vein thrombosis clinic. Materials and Methods: 44 patients admitted to the Karadeniz Technical University Faculty of Medicine and Trabzon Kamu Hastaneler Birliği Health Sciences University Ahi Evren Chest and Cardiovascular Surgery Training and Research Hospital, with suspect of deep vein thrombosis included in our study. Patients confirmed to have DVT by doppler ultrasonography named as DVT(+) group, and patients not confirmed to have DVT by doppler ultrasonography named as DVT (-). PTX-3 levels determined in blood samples and compared between these groups. Results: Median levels of D-dimer in DVT(+) group was 3.92 µg/ml (1.57-6.05), and in DVT(-) group was 1.47 µg/ml (0.97-2.37), and a statistically significant difference was found between these groups (p<0.05). Median levels of Pentraxin-3 in DVT(+) group was 0.42 (0.36-0.49) µg/ml, and in DVT(-) group 0.40 (0.37-0.49) µg/ml, and there was no significant difference found between these groups (p˃0.05). Conclusion: According to our study, PTX-3 is not a suitable diagnostic marker for the diagnosis of deep vein thrombosis. We think that the value of PTX-3 in the diagnosis of deep vein thrombosis now need to be confirmed with broader, controlled studies. Key words: Deep vein thrombosis (DVT), Pentraxin 3 (PTX-3), D-dimer, diagnosis