Dişi sıçanlarda ATP bağımlı potasyum kanallarının bloke edilmesi ya da açılmasının sol koroner arterin kısmi tıkanmasını takiben oluşan aritmiler üzerine etkisi

In this study, the effect of both ATP dependent potassium channel blocker (glibenclamide) and opener (pinacidil) on ischemia induced arrhythmia produced by ligation of smaller branch of left coronary arteries was researched.In the research, 30 Female Spraque-Dawley rats weighing 215 - 245 g. in 7-8 month old were used. Glibenclamide was given in 0, 5 mg/kg/100ul dose intraperitoneally 20 minute before coronary ligation and pinacidil was given in 0, 01 mg/kg/100ul dose intravenously from cocygeal tail vein 10 minute before coronary ligation. Electrocardiogram (ECG) and arterial blood pressure was recorded during the 30 minute of coronary ligation.Blood pressure decreased (P<0.05) immediately after the ligation in all group of animals. Glibenclamide decreased the incidence of ventricular tachycardia (VT) (P<0.05) but pinacidil did not in respect to control. The score of arrhythmia calculated by using the type and duration of arrhythmia observed during 30 minutes of ligation was decreased by glibenclamide which was significantly different from both control and pinacidil group.As a result, ATP dependent potassium channel blockage with glibenclamide is found to be effective to decrease arrhythmia occuring 30 minutes ischemia in rats. This effect of glibenclamide to decrease arrhythmia may depend on decreasing electrical heterogenity between nonischemic and ischemic area. This heterojenity may increase in pinacidil group because of pinacidil opens ATP dependent potassium channel in normal myocardial cells.