Development of solubility of low solubility drugs

Lipid-structured drug delivery systems are a method for developing to increase the bioavailability of low solubility drugs and to achieve their release in the GI system with controlled manner and at the highest level. In our study, it was aimed to increase the bioavailability of the BCS class II component Olanzapine by increasing the solubility and release it in a controlled manner by applying the Type IIIB method of this system, and to make solid from the oil formulations by using various adsorbents to give them good fluidity and to make it an oral drug form. Selecting the Type IIIB formulation with the highest dissolution capacity are surfactants such as Koliphor PS20, Koliphor PS60, Koliphor PS80, Koliphor CS12, Koliphor HS15, Labrasol ALF, Gelucire 48/15, Gelucire 44/14, co-surfactants Transcutol HP, Koliphor CS20, Coliphor ELP, Maisine CC, Peceol, Labrafac Liphofile 1349, Labrafac PG, Capryol 90, Lauroglycol 90 were used. The capacity of the excipients to dissolve Olanzapine was analyzed and formulations were prepared from the selected excipients, and the droplet size and polydispersity index (PDI) of those which one did not cloudy when diluted with pure water. As a result (Koliphor PS80: Transcutol HP (2: 1) and (4: 1)): PG (9: 1) formulations droplet size were below 100 nm and PDI below 0,3. It was evaluated positively for the solid dosage form stage as it is suitable for Type IIIB class formulations. Afterwards, these formulations were turned into an oral powder dosage form using adsorbents. The triangular phase diagram results were also good and formulation compared reference product with dissolution study. In this study, it was decided that Olanzapine, a BCS class II drug active substance`s solubility was increased with Type IIIB formulations and converted into a solid dosage form with adsorbents. It was decided to achieve faster dissolution and absorption compare reference product. Key Words: Olanzapine, BCS class II, LFCS Type IIIB, çözünürlük, oral drugs.