Relationship between endocan and atherosclerotic risk factors

Background: Endothelial dysfunction plays an important role in the pathophysiology of atherosclerosis and coronary artery disease (CAD). Previous studies suggested that human endothelial cell-specific molecule-1 (endocan) may be a novel endothelial dysfunction marker. This study aims to investigate the relationship between serum endocan concentration and atherosclerosis and relationship between serum endocan level and individual factors used to calculate 10 year risk of heart disease using ASCVD(Atherosclerotic Cardiovascular Disease) estimator. Methods: A total of 205 eligible patients were enrolled in this study. Serum endocan level was measured by enzyme-linked immunosorbent assay. Ten year risk of atherosclerotic heart disease were calculated for induvidual patients online using ASCVD risk estimator. Results: Backward linear regression analysis showed no correlation between serum endocan level and individual factors(age, gender, sytolic and diastolic blood pressure, smoking status, use of antihypertensive drugs) used to calculate ten year risk for coronary artery disease in ASCVD estimator. There was also no raltionship between serum endocan level and atherosclerosis. Conclusions: There was no significant realtionship between serum endocan concentration and atherosclerosis. We also found no correlation between serum endocan level and individal risk factors for atherosclerotic heart diseases used in ASCVD risk estimator. Key Words: Endocan, atherosclerosis, atherosclerotic cardiovascular disease estimator, coronary artery disease.