General anesthesia in geriatric dogs with propofol-isoflurane, propofol-sevoflurane, alfaxalone-isoflurane, alfaxalone-sevoflurane and their comparison of biochemical, hemodynamic and cardiopulmonary effects

In this study, frequently used propofol-isoflurane and propofol–sevoflurane in veterinary medicine were compared to a relatively new anesthetic combination alfaxalone-isoflurane and alfaxalone-sevoflurane for the effects on hematological, biochemical and physiological parameters. The study was performed on 40 geriatric dogs from different breeds and sexes required to be anesthetized for various surgical intervention. Dogs were randomly divided into 4 groups randomly and anesthesia protocols were applied. After induction of anesthesia with 6 mg/kg propofol in groups 1 and 2, isoflurane anesthesia was continued in group 1 and sevoflurane in group 2. After induction of 3 mg/kg alfaxalone anesthesia in groups 3 and 4, isoflurane anesthesia was continued in group 3 whereas sevoflurane in group 4. At the preanesthetic period, 15, 30, 45, 60 minutes and 60 minutes after the anesthesia, complete blood counts were performed. Serum ALT, AST, urea, creatinine values were measured during preanesthesia, perianesthesia 15-30. minutes and 60 minutes after anesthesia. Cardiopulmonary parameters and reflexes were evaluated before anesthesia and recorded at perianesthetic 5, 10, 15, 30, 45, 60 minutes and 60 minutes after full recovery. Patients were monitored during anesthesia. Duration and depth of the anesthesia with propofol-isoflurane, propofol–sevoflurane, alfaxalone–isoflurane and alfaxalone-sevoflurane were found to be satisfactory for surgery. Four anesthetic agents applied in geriatric dogs did not adversely affected the hematological and biochemical parameters. In conclusion anesthesia on geriatric dogs after induction of propofol and alfaxalone maintained with isoflurane or sevoflurane found to be safe.