Investigation of gnal polymorphisms in children with attention deficit hyperactivity disorder

The dopaminerjik receptors play an important role in the etiopathogenesis of attention deficit hyperactivity disorder (ADHD). Golf is essential for the activation of adenylate cyclase by D1- like receptors in striatum. The aim of this study to investigate rs8095592 and rs3892113 polymorfisms in GNAL which codes Golf protein. The other objectives of the study is to investigate the relationships between GNAL and ADHD types, age of diagnosis and family history.The patient group consisted of the 100 children aged 6-18 with ADHD from the department of Child and Adolescent Psychiatry at Gazi University. The control group were also recruited from the same place aged 7-18 with no psychiatric disorder. Excluding criteria were having IQ score lower than 70 and learning disability. Genetic analysis were performed with the venous blood samples, rs8095592 and rs3892113 polymorfisms in GNAL had been investigated.Findings were as follows; There was no statistically significant difference between ADHD and control groups for rs8095592 and rs3892113 polymorfisms. Yet GG genotype in rs8095592 was significantly higher in ADHD group and the group with positive family history. GG genotype in rs8095592 and TG genotypes in rs3892113 were predominantly higher in inattentive type. GG genotype in rs8095592 was also higher in the patient group who diagnosed at the age of 8 and before. However these relations were not statistically significant. The results of this study showed that rs8095592 polymorfism in GNAL could play an important role in ADHD genetics. Having allel A in rs8095591 could be protective for the people who had a family history for ADHD. Further researches are needed to confirm this result.Key words: Attention deficit- hyperactivity disorder, D1 like receptors, GNAL