The applications and synthesis of benzimidazole-2-ylidene ligand complexes of silver metal

Silver NHC complexes are widely interested class of complex for organometallic chemistry due to their medicinel abilities. Recently, the use of silver NHC complexes has been increased in antimicrobial and more recently as therapeutic antitumor agents. Silver N-heterocyclic carbene complexes have played a very important role in the development of other metal carbene systems. Transmetallation reactions using silver carbenes have been reported for a wide variety of transition metals particularly Au(I), Pd(II) and Ru(II). Therefore, new Ag-N-heterocyclic carbene complexes have been synthesized and antimicrobial activities and transmetallation reaction have been investigated to palladium and ruthenium The results of this study could be summarized in three main sections: 1) In the first chapter, 1,3-dialkylbenzimidazolium salts (1a-1j) were prepared and their structure were elucidated by spectroscopic techniques. 2) In the second part, Ag (I)-benzimidazol-2-iliden(2a-ı) complexes were synthesized from reaction of Ag2O with the NHC precursors, and all complexes were structurally elucidated by means of spectroscopy. 3) In the last chapter, the antimicrobial activities and transmetallation reaction of prepared Ag-NHC complexes were investigated to palladium and ruthenium. KEYWORDS: N-Heterocyclic carbene, silver NHC complex, antimicrobial activity, transmetallation reaction