Heart turcica centrifugal sol karıncık destek sisteminin in vitro kan testleri için geliştirilmesi

Patients need heart transplantation in order to recover from heart related diseases but there is shortage of donor. Left ventricular assist devices (LVADs) are developed for patients that are in the late stages of cardiovascular diseases. Heart Turcica Centrifugal (HTC) is the first centrifugal LVAD that is being developed in Turkey. In the previous stages of the development, HTC was brought to the stage of blood tests in order to determine its hemolytic performance. This thesis covers the development process of HTC for in vitro blood tests. First prototype of HTC was manufactured of biocompatible Ti-6Al-4V ELI for the in vitro blood tests. However, the driver magnets on the bottom of the impeller were not biocompatible, so a solution had to be developed. The first approach was to coat these magnet surfaces with biocompatible coatings such as Diamond Like Carbon (DLC) coatings. Those coating failed to solve the problem. In order to solve the problem a design modification has been made. Impeller of HTC was manufactured from two components, which encapsulated driver magnets and prevented their blood contact. HTC could be subjected to in vitro blood testing for hemolytic performance. During in vitro blood test ASTM International standards F1830 and F1841 will be used. A test loop with proper equipment will be prepared and HTC will be connected to this setup for the in vitro blood testing. According to the ASTM F1841, Normalized Index of Hemolysis (N.I.H.) will be calculated in every hour for test duration of 6 hours.