İnsan yemek borusunun biomekanik analizi ve matematiksel modellenmesi

In this thesis we applied basic principles and numerical models to study the mechanical function of the human esophagus during normal swallowing. The primary aim is to characterize and understand the mechanics of the human esophagus. To reach this goal, three interconnected study have been carried out: (J) analysis of biological data to quantify the relationship among bolus motion, motions of anatomical features and normal swallowing, (2) a fluid and solid mechanics study to find out relationship between flow and tension in the muscle wall of the esophagus of normal swallowing, (5) to predict wall geometry from tension in the muscle wall. biological data analysis is performed from the recorded manometrical data, which is collected during swallowing. We find out several functions of the human esophagus from this analysis. To interpret only manometrical data without radiographic images have lots of difficulties. Limited information can be from manometry. We attempted to combine fluid and solid mechanics. There is not enough study about combination of fluid and solid mechanics in the literature. We developed a mathematical model for this purpose. This model gave us ability to calculate tension in the muscle wall directly from wall geometry. In the last part of this study, we attempt to predict wall geometry during swallowing. We predicted wall geometry from tension. This study gives us opportunity to interpret and understand in detail esophageal functions in the absence of radiography.