Investigation of 8q24 (rs6983267) gene polymorphism related to prostate cancer

This thesis explores the rs6983267 gene polymorphism at the 8q24 locus, which is thought that is related with the development of prostate cancer. The study aims to assess the impact of this genetic variation on the development of prostate cancer and its potential biological mechanisms. The research was performed by using real time Polymerase Chain Reaction (RT-PCR) and genotyping analyses on a broad patient population. The study was completed with a total of 171 men. 93 men had PCa therefore formed the "case" group, remaining 78 men formed the control group. Several studies and meta-analysis have been done by various researchers; and showed the relationship between PCa and 8q24 (rs6983267) gene polymorphism. However in our study 39.8 % of the "Case" group has GT genotype. The percentage of GT genotype is 34.5% among the "Control" group. The p-value is 0.352 pointing to a non-significant difference. This association has been examined across different age groups, and environmental factors. Furthermore, the cellular effects of rs6983267 and its role in cancer development have been investigated using molecular biology techniques. This thesis highlights the significance of the rs6983267 gene polymorphism as a potential biomarker for both diagnosis and treatment of prostate cancer. It also suggests new avenues for future research. Key Words: Polymorphism, 8q24, rs6983267, Prostate Cancer