The investigation of the inhibitory potentials of some polyphenols for acetylcholinesterase activity

The AChE enzyme is the primary subject of this work. Acetylcholinesterase inhibitors are used as appropriate medications and toxins because they interact with the enzyme as their primary target. Therefore, investigating the potential of polyphenols to prevent AChE was the primary aim of this research. There have been studies on molecular docking, and the ability of compounds to inhibit the AChE enzyme was tested. Results from in vitro and silico experiments suggested that the 3 compounds could function as AChE inhibitors. "(2R,3S)-3,5,7-tris(benzyloxy)-2- (3,4-bis(benzyloxy)phenyl) chromane " compound showed adequate drug-like properties and potent inhibitory properties against the enzyme, with IC50 values of 13.59 μM, " (E)-3,5-bis(benzyloxy)-2- (3-(3,4,5-tris (benzyloxy)phenyl)allyl) phenol " compound exhibited preventing action against the enzyme as well, with IC50 values of 15.07 μM and " (2R,3S)-5,7-bis(benzyloxy)-2- (3,4,5-tris (benzyloxy) phenyl) chroman-3-ol" compound with IC50 values of 15.75 μM, the substance exhibited inhibitory properties against the enzyme. Additionally, the Swissadem and pkCSM web servers scanned all compounds' predictive qualities for drug similarity using ADMET.