The comparision between endomyocardial biopsy results and blood pro-bnp level to diagnose acute rejection at hearth transplant patients

Heart failure is still with high mortality and morbidity. It decreases the life quality of the patient. Despite medical therapy and asist devices that developed recently, it has still bad prognosis. Every year, every 10% of heart failure patients proceed to end-stage disease. Heart transplantation is an effective method of tratment which increases the survival and life quality of those patients. The most important reasons of mortality and morbidity after heart transplantation are; acute rejection, infections, malignencies, coronary allograft vasculopathy and renal insufficiency due to immunosuppressive drugs. Endomyocardial biopsy is still the gold standart method to diagnose rejection. Because this is an expensive and invasive method, resaerches to improve an alternative mehod are increasing. Altough this study is made with a small number of patients, it showed us that, non-invasive examinations can not be an alternative to endomyocardial biopsy which is stil gold standart. But the results of those examinations can be suspicious for rejection. The close follow-up of patients and usage of those non invasive examination methods with clinical experience, can be important fort the early rejection diagnosis and can decrease the total number of endomyocardial biopsies. Those non-invasive methods are not alternative methods for endomyocardial biopsies, but they can be helpful and guiding. Its obvious that, more extensive and prospective studies are needed to estimate the value of those methods