Kontrollü ilaç salımı için yeni geliştirilen ph'a duyarlı hibrid hidrojellerin görünür ışık altında sentezlenmesi

In the current research on drug delivery systems hydrogels have become an important topic due to their unique properties such as high water content and sensitivity to the physiological changes in the body. In this study, a novel method was developed for the visible-light-induced synthesis of a pH responsive composite hydrogels for controlled delivery of an anticonvulsant model drug pregabalin (PGB). The pH sensitive layer of the composite hydrogel was based on methacrylic acid grafted with poly(ethylene glycol) tethers P(MAA-g-EG). In addition, the hydrogel was functionalized with hydrophobic domains, through incorporation of crosslinked styrene-butadiene-styrene (SBS) copolymer. Swelling ratios were decreased with the addition of SBS, and as a result high hydrogel crosslink densities were observed. The composites were investigated for controlled release of PGB, and the release was analyzed to describe the mode of transport through the network under neutral and low pH conditions. In vitro human fibroblast survival assay and in vivo rabbit implantation experiments demonstrated that, these hybrid hydrogels were not toxic and had desirable biocompatibility properties. This is the first report about the synthesis of a pH responsive composite hydrogels via visible light photopolymerization. This technique could be useful for incorporation of molecules with specific functionalities so that sequential molecule delivery in response to specific stimuli could be achieved. This approach can also be used for the design of multifunctional membranes for various tissue engineering applications.