The assosication between fabp-1 levels and histopathologic features in chronic hepatitis B, chronic hepatitis C and nonalcholic fatty liver disease

SUMMARYChronic hepatitis C (CHC), Chronic hepatitis B (CHB) and non alcholic fatty liver disease are quite common in population. Liver biopsy is still regarded as the gold standard for the staging of histological activity in these diseases. Various molecules are presently being studied for determining a optimal noninvasive marker for decision making before treatment, follow up and disease progression.FABP-1?s molecular weight 15 kDA and has high concentration in hepatocytes. Inconsiderable production in other tissues has led to high specifity. As far as we know there is no report for evaluating the relationship between FABP-1 and hepatocyte injury on the basis of histopathologic findings.In our study we aimed to identify this relation in patients with chronic viral hepatitis and NAFLD. We evaluated 89 patients (CHC: 20, CHB:51 and NAFLD:18) with liver biopsy and 40 healthy volunteers. Histological findings were evaluated blindly according to the Ishak and the Brunt classifications for CHB/CHC and NAFLD respectively. Serum FABP-1 levels significantly higher in CHC:2.8 and NAFLD:3.4 ng/ml, compared to control grup. Also within the groups there was difference in FABP-1 levels according to NİA ve FE grades.As these results supported through studies with large numbers, FABP-1 would be marker for hepatocyte injury.