Malatyadaki tüberküloz hastalarında bazı tlr genlerinin polimorfizmlerinin taranması

Tuberculosis, one of the major health problems causes many deaths every year in the world. According to the report of World Health Organization, 2 million people per year lose their lives due to tuberculosis. The disease can remain in the latent phase for a very long time after infecting the affected individual. Although some of the infected people are showing the symptoms, while in some people the disease never develops, even about 90% of them are improved by the immune system's response. As in many infectious diseases, the difference between the number of infected people and the number of sick people is caused by differences in balance between host defense and the virulence of the organism. In studies conducted this difference was mostly attributed to the state of the immune system of the site, but not to an adequate response. In this case, the genetic basis of the response to infectious agents needs to be investigated in order to understand the relationship between infectious diseases and host. We also investigated the effect of polymorphisms in TLR genes from the genes involved in immune response to susceptibility to Mycobacterium tuberculosis. In this thesis study, we included 50 tuberculosis patients and 50 healthy individuals living in Malatya. Patient and control groups were compared in terms of TLR 4 (rs4986790, rs4986791) and TLR 6 (rs3821985) genotype and allele distributions and we did not find a statistically significant result between them.