Manyetik sıvı kullanarak yapılan odaklanmış radyo dalga ablasyonu

In most developed countries, cancer is presently responsible for about 25% of alldeaths. Heat therapies like hyperthermia and thermoablation are very promisingapproaches in the treatment of the cancer. Since these are physical treatmentmethods they have fewer side affects compared to chemo- and radio-therapy.Currently, various types of heat treatment modalities are available like microwave,ultrasound, RF capacitance hyperthermia, RF probe hyperthermia, magnetic fluidhyperthermia, but non of these methods have the ability to accurately deliver highheat energy to deeply seated tumors without damaging the healthy surroundingtissues.In this thesis, a novel RF ablation system was developed capable of focusing theheat in to very small areas in the order of millimeters, which will allow heating ofthe tumors without destroying collateral normal tissues. Generally, in this systemthe tumor ablation is achieved via coupling RF energy on the magnetic fluids whichare previously dispersed in to the tumor tissue.By considering the human safety limits (nerve stimulation and tissue eddy currentheating safeties) optimum treatment parameters like particle size of the magneticfluids, frequency and strength of the applied RF field are obtained. The utilizationof the optimum parameters may lead to the very effective operation of the ablationsystem where treatments can be done with very small amounts of fluid injections, inshort durations.We believe that by the studies conducted in this thesis, magnetic fluid hyperthermia(tumor ablations using magnetic fluids) can be a much more effective method sothat it can be used as the one of the most important tumor treatment techniques infuture.Key words: Tumor Therapy, Hyperthermia, Thermo ablation, Magnetic FluidHyperthermia, Magnetic Fluids, Focused Ablation.