The releationship between HER-2/neu level and hormone receptor status with treatment results in 640 breast cancer patients

There was many prognostic factors for detection of treatment method, providefor treatment response and estimating treatment outcomes in breast cancer.Hormone receptor status and HER-2/neu levels have undoubtedly greatimportance in this prognostic factors.In this study, the ER status, PR status and HER-2/neu levels and their impactat overall and disease-free survival are evaluated in 640 patients with breast cancerwho are curatively treated in Gazi University Faculty of Medicine, RadiationOncology Department. The average age of patients are 49,7, range from 20,8-79,4. The mean follow-up time was 59,1 months.The patients survival analysis were found with SPSS version 16.0 usingKaplan-Meier method for overall survival and disease-free survival. Log Rank testwas used for the aim of comparison of prognostic factors. Statistical results werecalculated seperately for each prognostic factor.Estrogen receptor and PR positivity were significantly increased both overalland disease-free survival and their importance for prognosis were shown. Theover-expression of HER-2/neu was adversely affect overall and disease-freesurvival. While these prognostic factors evaluated together the worst prognosis hasbeen shown in ER(-), PR(-), HER-2/neu(+) patients.Based on the study results, ER, PR and HER-2/neu levels have greatimportance in breast cancer and must be well considered in patients follow-up.Keywords: Breast cancer, Prognosis, Hormone receptor and HER-2/neu.