The evaluation of in vitro antioxidant, antimicrobial properties and COX-1/COX-2 enzym inhibitory activity of mentha pulegium

Medicinal and aromatic plants and spices have been used by people throughout history to treat diseases. Mentha pulegium is used as food in the world and in our country, as well as in traditional treatments. In this context, the presented study was carried out to examine the antioxidant and antimicrobial properties of the Mentha pulegium plant and its effects on COX-1 and COX-2 enzymes. Antioxidant properties were investigated spectrophotometrically by DPPH and CUPRAC methods, while antibiotic effect was determined by disk diffusion method. The effects on COX-1 and COX-2 enzymes were determined colorimetrically with commercial kits. The results obtained showed that Mentha pulegium plant had a significant antioxidant effect, while it did not have any antibiotic effect on Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli and Candida albicans strains. On the other hand, it exhibited a very weak inhibition effect on the COX-1 enzyme. The effect on the COX-2 enzyme could not be calculated. As a result, it was determined that the plant Mentha pulegium has an important antioxidant property and has a very weak inhibition effect on the COX-1 enzyme