Comparision of the properties of clinicopathological methastatic lung carcinoma diagnosed patients and examination of whether the associated with long survival

Lung cancer is one of the most frequent cancers in the world. In the non-small cell lung cancer (NCCLC), the most important prognostic factors that effect survival are; histopathologic type, tumor grade, the patient's performance, weight loss, age, gender, serum LDH, ALP, calcium and hemoglobin levels and genetic factors. In this study we investigated the presence of the possible new factors which effect the long survival in NCCLC that is 85% of the lung cancers. The patients (totally n=100) who were treated and followed in Karadeniz Technical University, Medicine Faculty, internal medicine, medical oncology and pulmonology departments between January 2010 and September 2015 and who had metastatic NCCLC were included to the study. Our study conducted as retrospectively and also prospectively. 50 patients who had died were included and evaluated retrospectively. Prospectively, 50 patients were followed at least 6 months in terms of survival. Statistical analysis were performed by using SPSS, version 23 software. The univariate analysis on survival performed by using log rank test. In the multivariate analysis, the independent factors which were the possible factors that determined by previous studies in survival prediction was evaluated by using cox regression analysis by backward selection method. In our study, age, gender, living place, family type, presence of lung cancer and other cancers in the family and degree of relatives, alcohol abuse, presence of smoking (if smokes, the amount of pack per year), smoking after the diagnosis of lung cancer, pathological findings, presence of fever, night sweats and weight loss, co-morbid diseases (diabetes, hypertension, coronary artery disease, chronic obstructive pulmonary disease), performance status (ECOG), body mass index, calcium, LDH, ALP, LDL, glucose and albumin levels, leukocyte, neutrophil, basophil and eosinophil counts, presence of a surgery due to primary tumor, presence of history of tuberculosis, metastasis zones (soft tissues, liver, brain, bone etc.), chemotherapy status and protocols, targeted therapy status, radiotherapy status and sites of body were evaluated. According to the results of our study, in univariate analysis; absence of chronic obstructive pulmonary disease (p=0.032), presence of good performance score (p<0,001), absence of hypercalcemia (p<0.001), normal LDH level (p<0,001), albumin level over 3 gr/dl (p=0,004), normal basophil counts (p=0,002), absence of liver metastases (p=0,017), chemotherapy treatment (p<0.001) and radiotherapy to the lung (p=0.036) were the prognostic factors that related with long survival. Also, in both univariate and multivariate analysis showed that normal LDH level, presence of good performance score is related with long term survival. There was no statistically significance in other parameters. As a result, in NCCLC there are significant prognostic factors, but further studies are needed.