Investigation of milnacipran and sertraline's effect on inflammation and pain with two different models

Tricyclic antidepressant (TCA) and selective serotonin re-uptake inhibitors (SSRIs) are widely used drugs for the treatment of psychiatric disorders. Used clinically as an antidepressant and anti-inflammatory analgesic effects of these drugs are also shown in animal and human studies. Primarily as an analgesic drugs in the clinic in both groups are preferred in the treatment of neuropathic pain. The studies both noradrenaline and serotonin reuptake inhibitor antidepressants, although it is effective in relieving pain, anti-inflammatory effects have been observed in the differences between them.In this study both serotonin and noradrenaline re-uptake inhibitor (SNRI) milnacipran, and selective serotonin re-uptake inhibitor (SSRI) sertraline?s effect on inflammation and pain and the mechanisms of these effects was investigated by using two different models. In the study, tail-flick was used to assess pain and formalin test was used to assess inflammation. As a result of the study milnacipran?s statistically significant (p<0,05) analgesic effect was observed at doses of 30mg/kg and 50mg/kg. Statistically significant (p <0.05) anti-inflammatory effect of milnacipran was observed at a dose of 50mg/kg which was significantly reduced all the parameters evaluated in the formalin test. Sertraline?s statistically significant (p<0,05) analgesic effect was observed at a dose of 50mg/kg. Sertraline?s anti-inflammatory effect wasn?t observed at doses studied. Sertraline wasn?t found antiinflammatory at doses studied.Mechanism studies were investigated over the opioidergic, serotonergic, noradrenergic and nitrergic systems. The observed analgesic and anti-inflammatory effects all the systems were found to play a role.